Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus

SHEN Li; ZHU Li; LUO Qian; LI Xiao-Wen; XI Ju-Qun; KONG Gui-Mei; SONG Yong-Chun

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Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus

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The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I(1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C(2), rhizoctonic acid(3), monomethylsulochrin(4), chaetominine(5), spirotryprostatin A(6), asperfumoid(7), and lumichrome(8). The structure of compound 1 was elucidated by various spectroscopic analyses(UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MTT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent.

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《中国天然药物：英文版》 |2015年第12期|937-941|共5页
作者
SHEN Li; ZHU Li; LUO Qian; LI Xiao-Wen; XI Ju-Qun; KONG Gui-Mei; SONG Yong-Chun;
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作者单位

Medical College;

Yangzhou University;

Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses;

Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases;

Institute of Functional Biomolecules;

Nanjing University;

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原文格式 PDF
正文语种 chi
中图分类有效成分的分离与提取;
关键词
Endophyte; Aspergillus; terreus; Chemical; constituent; Ergot; alkaloid;

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Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus

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