Chemical constituents of Euphorbia tibetica and their biological activities

YANG Da-Song; HE Qiu-Xia; YANG Yong-Ping; LIU Ke-Chun; LI Xiao-Li

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Chemical constituents of Euphorbia tibetica and their biological activities

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AIM: To investigate the chemical constituents and their biological activities of the aerial parts of Euphorbia tibetica. METHOD: Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated through the use of extensive spectroscopic techniques including 2D-NMR, the structures of compounds 5 and 6 were confirmed by single-crystal X-ray crystallography. Bioactivities of all the isolated compounds were evaluated by the MTT method on A549 and anti-angiogenesis assay. RESULTS: One new compound, methyl 4-epi-shikimate-3-O-gallate(1), together with twenty-three known constituents(2–24) were isolated from the aerial parts of E. tibetica. CONCLUSION: Compound 1 is new, and the other compounds were isolated from this plant for the first time. Compounds 5–7, 9, 11, 17, 18 and 20 exhibited inhibitory effects on the growth of human lung cancer cell A549 and compounds 5, 7, 12, 13, 17 and 19 showed anti-angiogenic effects in a zebrafish model.

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《中国天然药物：英文版》 |2014年第1期|38-42|共5页
作者
YANG Da-Song; HE Qiu-Xia; YANG Yong-Ping; LIU Ke-Chun; LI Xiao-Li;
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作者单位

Key Laboratory of Economic Plants and Biotechnology;

Germplasm Bank of Wild Species in Southwest China;

Institute of Tibetan Plateau Research at Kunming;

Kunming Institute of Botany;

Chinese Academy of Sciences;

Biology Institute of Shandong Academy of Sciences;

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原文格式 PDF
正文语种 chi
中图分类化学分析与鉴定;
关键词
中药学; 中药材; 植物药; 药理分析;

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Chemical constituents of Euphorbia tibetica and their biological activities

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