Placenta is a membranous structure that separates maternal and fetal circulation. The physiological anatomy, developmental stage and fetal circulation determine the placental transport of anesthetics. Most of the clinical anesthetics can easily cross the placenta barrier and cause significant hazard for neuro-toxicity. The techniques to study the placental barrier permeabil-ity include the in vivo and in vitro techniques. For details on these aspects, the paper summarizes the research about the placental transport of clinical anesthetics in common use and introduces the techniques to study the placental barrier permeability.%胎盘是胎儿与母体之间进行物质交换的器官,胎盘屏障在物质交换中起到重要的防御作用.胎盘的生理解剖、发育过程的不同阶段及胎儿循环决定了麻醉药物的胎盘转运基础.从目前的研究中发现,几乎所有临床常用麻醉药物都能通过胎盘屏障,对新生儿神经发育产生不同程度的影响.对胎盘屏障通透性的研究方法也在逐步改进,包括在体和离体等多种手段.为此,该文将概括目前临床常用麻醉药物胎盘转运情况的研究进展,并简要介绍有关胎盘屏障通透性的研究方法.
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