Objective To explore the treatment of chronic infective wounds .Methods A retrospective analysis of clinical data in 225 patients were admitted from 2000 to 2010 .Results (1) They were mainly traumatic ulcers ,pressure ulcers ,postoperative ul-cers ,diabetes ulcers ,vascular ulcers in the group ,accounted for 80 .4% (181/225) .(2) Bacterial culture positive rate was 87 .1%(196/225) ,a total of 46 kinds with 342 pathogens were cultured ,gram-positive bacteria 40 .6% (139/342);gram-negative bacteria 57 .6% (197/342);Fungi 1 .8% (6/342) .The main pathogens were S .aureus(52) ,E .coli(43) ,P .aeruginosa(44) ,Klebsiella .SPP (27) ,which were highly resistant to penicillin ,erythromycin ,ampicillin ,gentamicin ,cotrimoxazole and the multidrug resistance rate was 37 .1% (127/342) .Chronic wounds and multidrug resistant bacteria showed rapidly increasing trend from 2007 .(3) 201 pa-tients with topical antibiotic treatment ,208 patients(49 patiens underwent re-operation)underwent operations to close wounds ;213 patiens were recovery ,12 patiens had to leave hospital because economic burden .Conclusion Chronic infective wounds were affect-ed by many factors .emphasizing on debriding ,reasonablechoice ,circulative ,alternate use of antibiotics and wound bed preparation , appling surgery to close wounds in early stage could effectively control wound infection and promote wound healing .%目的：探讨慢性感染性创面的治疗。方法回顾性分析2000～2010年该院收治225例慢性感染性创面患者的临床资料。结果（1）慢性感染性创面以创伤性溃疡、压疮、术后溃疡、糖尿病性溃疡、血管性溃疡为主，占80．4％（181/225）。（2）创面细菌培养阳性率为87．1％（196/225），共培养46种，342株病原菌，革兰阳性菌40．6％（139/342），革兰阴性菌57．6％（197/342），真菌1．8％（6/342），以金黄色葡萄球菌（52株）、大肠埃希菌（43株）、铜绿假单胞属（44株）、肺炎克雷伯（27株）等为主，对青霉素、红霉素、氨苄西林、庆大霉素、复方新诺明等高度耐药，多重耐药率达37．1％（127/342）。从2007年后慢性创面及多重耐药菌呈迅速增加趋势。（3）201例行局部抗菌药物治疗，208例（49例行再手术）行手术封闭创面治疗，213例治愈，12例因经济等原因未愈出院。结论慢性创面感染受多种因素共同影响，注重清创，合理的选择，循环、交替使用抗菌药物以及创面床准备，早期手术封闭创面，能有效控制创面感染，促进创面愈合。
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