Objective To investigate the clincial efficacy of nicardipine in the prevention of adverse cardiovascular re-action of patients with laparoscopy myomectomy induced by pituitrin. Methods One hundred and eight cases of patients with laparoscopy myomectomy were randomly divided into observation group(60 cases) and control group(48 cases). Under the same conditions of the surgical anesthesia, both groups were given corpus injection of pituitrin. And then, the observa-tion group was given intravenous injection 10 μg/kg of nicardipine at 2 minutes after injecting pituitrin, while the contorl group was given intravenous injection 5 ml of 0.9 % sodium chloride injection. The mean arterial pressure (MAP), heart rate(HR), and ECG indexes at one minute(T0) before medication of pituitrin and 30 seconds(T1), 1 minute(T2), 2 min-utes (T3), 5 minutes (T4), 10 minutes (T5) and 30 minutes (T6) after medication of pituitrin were compared between two groups. Results The MAP levels of both groups at T1,T2 points were significantly decreased while the HR levels were significantly increased when compared to T0 point (t=28.19, 20.10, 23.94, 16.53, 8.65, 11.88, 8.50, 10.34, P<0.05). The MAP levels of observation group at T4,T5,T6 points were not significantly different with T0 point (t=1.26, 0.76, 1.16, P>0.05), but the HR levels were significantly different(t=7.62, 10.23, 5.03, P<0.05). The MAP levels of control group at T4,T5,T6 points were significantly increased while the HR levels were significantly decreased when compared to T 0 point (t=10.72,12.49,12.84,7.62,10.23,5.03,P <0.05). The MAP levels of observation group at T4,T5,T6 points were significantly lower than those of the control group while the HR levels were significantly higher than the control group (t=8.00, 9.52, 10.55, 17.14, 22.00, 13.00, P<0.05). The incidence rates of atrial premature beats, premature ventricular beats, si nus bradycardia, AVNRT and Q-T prolongation in observation group were significantly lower than those of the control group (χ2=4.74, 11.09, 4.74, 6.01, 7.58, P<0.05). Conclusions Nicardipine is effective for the prevention of the increasing of MAP and slowing down the HR responses that induced by pituitrin in patients with laparoscopy myomectomy , so that can reduce the risk of adverse cardiovascular responses induced by pituitrin.%目的：探讨尼卡地平预防垂体后叶素诱发腹腔镜下子宫肌瘤切除术患者心血管不良反应的临床效果。方法选择行腹腔镜子宫肌瘤切除术患者108例，随机分为观察组60例和对照组48例。在相同的手术麻醉条件下，均给予垂体后叶素宫体注射，观察组垂体后叶素注射2 min后给予尼卡地平10μg/kg静脉注射，对照组给予0.9％氯化钠注射液5 ml静脉注射，比较两组患者垂体后叶素用药前1 min（T0）、用药后30 s（T1）、1 min（T2）、2 min（T3）、5 min （T4）、10 min（T5）以及30 min（T6）时平均动脉压（MAP）、心率（HR）及心电图检测指标变化情况。结果与T0时刻比较，两组患者在T1、T2时刻MAP水平明显降低，HR水平明显升高，差异均有统计学意义（t分别=28.19、20.10、23.94、16.53、8.65、11.88、8.50、10.34，P均＜0.05）。与T0时刻比较，观察组患者在T4、T5、T6时刻MAP水平无统计学意义（t分别=1.26、0.76、1.16，P均＞0.05），HR水平明显升高，差异均有统计学意义（t分别=7.62、10.23、5.03，P均＜0.05）；与T0时刻比较，对照组患者在T4、T5、T6 MAP水平明显升高、HR水平明显降低，差异均有统计学意义（t分别=10.72、12.49、12.84、7.62、10.23、5.03，P均＜0.05）；观察组患者在T4、T5、T6时刻MAP水平明显低于对照组，HR水平明显高于对照组，差异均有统计学意义（t分别=8.00、9.52、10.55、17.14、22.00、13.00，P均＜0.05）。观察组患者房性早搏事件、室性期前收缩、窦性心动过缓、交界性心动过速以及Q-T延长的发生率明显低于对照组，差异均有统计学意义（χ2分别=4.74、11.09、4.74、6.01、7.58，P均＜0.05）。结论尼卡地平能够有效预防腹腔镜下子宫肌瘤切除术患者宫体局部注射垂体后叶素所引起的MAP增加以及HR减慢反应，降低垂体后叶素诱发心血管不良反应风险。
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