目的：分析喹诺酮类抗菌药的不良反应，探讨临床合理用药对策。方法选取在本院服用喹诺酮类抗菌药引起不良反应患者120例，回顾性分析其临床资料，统计使用药物种类及不良反应等，总结合理用药对策。结果左氧氟沙星的不良反应发生率最高（38.3%），依诺沙星最低（5.0%）。不良反应主要表现为变态反应，以及累及神经、呼吸、消化系统等，分别占40.0%、23.3%、12.5%、24.2%。结论需加大对喹诺酮类抗菌药使用的监管力度，合理应用，并采取有效措施预防不良反应的发生。%Objective To analyze the adverse reactions and clinical rational drug use of quinolones. Methods One hundred and twenty patients who taking quinolone antibacterial agents were selected, and the clinical data were retrospectively analyzed. The types of drugs and adverse reaction were recorded, and the methods of rational drug use were summarized. Results The highest incidence of adverse drug reactions was levofloxacin (38.3%), while the lowest was enoxacin (5%).The main adverse reactions were allergic reaction, involving nerve, respiration and digestion systems, accounting for 40.0%, 23.3%, 12.5%, 24.2%respectively. Conclusion It is necessary to intensify supervision on the use of quinolones and reasonable application. The effective measures should be taken to prevent the incidence of adverse reaction.
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