Objective Helicobacter pylori (HP) infection in gastric interleukin mRNA levels.Methods A retrospective analysis of our hospital for examination and treatment of 52 cases of chronic gastriti from October 2010 to June 2013,HP-positive patients were treated using real-time PCR, PCR-lfuorescence probe method and sandwich enzyme-linked immunosorbent assay was used to detect patients with gastric interleukin m RNA (IL-6, IL-1β) levels,recorded before and after treatment m RNA (IL-6, IL-1β) levels. To investigate the correlation between Helicobacter pylori infection. Results The study showed that patients with gastric interleukin m RNA levels increased with H. pylori infection and elevated levels of IL-6 in particular, with the extent of the infection worsening. Meanwhile, the degree of infection as compared to the patients before and after treatment from a lower decrease in the serum of gastric mucosal protein levels of IL-6 activity. The IL-1β levels were not signiifcantly changed.Conclusion The effect on Helicobacter pylori infection m RNA is not signiifcant,while IL-6 and Helicobacter pylori infection is closely related.%目的：研究幽门螺杆菌(Helicobacterpylori,HP)感染中胃黏膜白细胞介素mRNA水平。方法选取2010年10月～2013年6月在中山市民众医院接受检查治疗的慢性胃炎患者52例，将收治的HP阳性患者分别采用real-time PCR、PCR-荧光探针法及酶联免疫吸附实验夹心法检测患者胃黏膜白细胞介素mRNA(IL-6、IL-1β)的水平，记录治疗前后mRNA(IL-6、IL-1β)水平，探讨与幽门螺杆菌感染相关性。结果患者胃黏膜白细胞介素mRNA水平随着幽门螺旋杆菌感染加重而升高，尤其是IL-6水平，随着感染程度的不断恶化。同时，治疗前后相比患者的感染程度从降低，其血清与胃黏膜蛋白中的IL-6活性水平降低，而IL-1β水平无明显变化。结论幽门螺杆菌感染对mRNA的影响不显著，而IL-6与幽门螺杆菌的感染有着密切的关系。
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