Objective To determine the effect of humoral reactions in children with pulmonary edema after enterovirus-71-related hand, foot and mouth disease. Methods Children who confirmed infected by enterovirus-71 were divided into three groups:8 patients with pulmonary edema, 30 patients with central nervous system (CNS) involvement but no pulmonary edema and 52 patients without complications. And serum immunoglobin and complement (C3, C4) were detected by immunoturbidimetry. Results Serum IgG levels in children with pulmonary edema and children with CNS complications but no pulmonary edema was (10.99±1.67) and (8.03±1.27) respectively, which significantly higher than that (5.63±0.12) in patients without complications(F=6.287, P<0.05). However, there was no difference between them. Serum levels of IgA and IgM were found to be no difference among three groups. Compared with patients in other two groups, patients who experienced pulmonary edema had decreasing C3 levels (F=3.715,P=0.029). So were serum levels of C4. Conclusion Humoral reactions probably were not involved in children with pulmonary edema after enterovirus-71-related hand, foot and mouth disease.% 目的探讨体液免疫机制在EV71相关手足口病合并肺水肿中的作用.方法将90例经鉴定为EV71感染患儿分为脑炎合并肺水肿组8例,单纯脑炎组30例,剩余52例为无并发症组.采用免疫比浊法,对90例EV71感染引起的手足口病患儿血清免疫球蛋白(IgG、IgA及IgM)及补体C3、C4含量进行检测.结果脑炎合并肺水肿组及单纯脑炎组患儿血清IgG的平均含量分别为(10.99±1.67)g/L和(8.03±1.27) g/L,差异无统计学意义；但与无并发症组的(5.63±0.12)g/L比较,明显升高,差异有统计学意义(F=6.287,P<0.05).患儿血清IgA及IgM含量三组之间比较差异无统计学意义(P>0.05).与其他两组相比,脑炎合并肺水肿组患儿血清C3、C4平均含量明显降低,差异有统计学意义(F=3.715,P=0.029).结论在EV71引起的手足口病合并肺水肿的病程中体液免疫反应可能并不参与.
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