Intra-host Ebola viral adaption during human infection

Liu William J.; Shi Weifeng; Zhu Wuyang; Jin Cong; Zou Shumei; Wang Ji; Ke Yuehua; Li Xiaofeng; Liu Mi; Hu Tao; Fan Hang; Tong Yigang; Zhao Xiang; Chen Wenbin; Zhao Yuhui; Liu Di; Wong Gary; Chen Chengchao; Geng Chunyu; Xie Weiwei; Jiang Hui; Kamara Idrissa Laybor; Kamara Abdu

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Intra-host Ebola viral adaption during human infection

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The onsite next generation sequencing （NGS） of Ebola virus （EBOV） genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin, transmission, and evolution of this virus. Herein, we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015, during the late phase of the outbreak. The surviving EBOV patients had a recovery process characterized by decreasing viremia, fever, and biochemical parameters. EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection, including the previously described short stretches of 13 serial T＆C mutations. Remarkably, within individual patients, samples collected during the early phase of infection possessed Ts at these nucleotide sites, whereas they were replaced by Cs in samples collected in the later phase, suggesting that these short stretches of T＆C mutations could emerge independently. In addition, up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently. Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions.

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《生物安全与健康（英文）》 |2019年第1期||共页
作者
Liu William J.; Shi Weifeng; Zhu Wuyang; Jin Cong; Zou Shumei; Wang Ji; Ke Yuehua; Li Xiaofeng; Liu Mi; Hu Tao; Fan Hang; Tong Yigang; Zhao Xiang; Chen Wenbin; Zhao Yuhui; Liu Di; Wong Gary; Chen Chengchao; Geng Chunyu; Xie Weiwei; Jiang Hui; Kamara Idrissa Laybor; Kamara Abdu;
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1. NHC Key Laboratory of Biosafety 2. National Institute for Viral Disease Control and Prevention 3. Chinese Center for Disease Control and Prevention 4. Beijing 102206 5. China 6. Institute of Disease Control and Prevention 7. Academy of Military Medica;

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正文语种 chi
中图分类经济;
关键词
Ebola virus; Intra-host Nucleotide Variation; Adaptation; Genome sequencing; Clinical manifestations; Blood biochemistry;

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Intra-host Ebola viral adaption during human infection

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