OBJECTIVE:To investigate problems in prescriptions of antibiotics in pediatric outpatient in Maternal and Child Health Hospital of Chenzhou ( hereinafter referred to as "our hospital") , so as to provide references for clinical rational application and scientific management of antibiotics .METHODS:674 prescriptions of antibiotics in pediatric outpatients in our hospital were randomly extracted and retrospectively analyzed according to dispensatories , literatures and handbooks published home and abroad , textbooks, Prescription Administration Policy , Administration Policy for Clinical Application of Antibiotics , Guiding Principles for Clinical Application of Antibiotics , Chinese Pharmacopoeia-Clinical Medication Instructions (2010 Version).RESULTS:Clinical diagnoses of 33 kinds of diseases were involved in the 674 prescriptions , the top 5 diseases ranked in the number of prescriptions were respectively bronchitis, pharyngitis, amygdalitis, bronchopneumonia and gastritis; 27 kinds of antibiotics were involved ( not including those for local application and external use ) , with 798 times of using in total , the top 5 antibiotics were respectively cefixime for suspension , ceftazidime for injection , cefoperazone-sulbactam for injection , azithromycin for injection and piperacillin-sulbactam for injection .Of the 674 prescriptions , there were 343 irrational prescriptions ( 50.9％) , mainly including the types of incomplete writing of clinical diagnosis , not prescribe under the administration policy of antibiotics , inappropriate indications , inappropriate drug selection , improper usage and dosage , non-indication medication , repetitive medication , adverse drug interactions . CONCLUSIONS: Irrational application of antibiotics in pediatric outpatient in our hospital is still exist , which needs to be reinforced on its administration and gives full play of clinical pharmacists , clinicians-pharmacists collaboration needs to be enhanced so as to promote clinical rational medication .%目的:了解郴州市妇幼保健院(以下简称"我院")儿科门诊抗菌药物处方中存在的问题,为临床合理应用和医院科学管理抗菌药物提供依据.方法:随机抽取2016年我院儿科门诊抗菌药物处方674张,依据药品说明书、公开发表的国内外文献与指南、教材书、《处方管理办法》《抗菌药物临床应用管理办法》《抗菌药物临床应用指导原则》及《中华人民共和国药典·临床用药须知》(2010年版)等对处方进行回顾性分析.结果:674张处方涉及33种疾病的临床诊断,抗菌药物处方数排序居前5位的病种分别为支气管炎、咽炎、扁桃体炎、支气管肺炎和胃炎;涉及27种抗菌药物(不包括局部使用制剂和外用制剂),共使用798例次,排序居前5位的抗菌药物分别为头孢克肟干混悬剂、注射用头孢他啶、注射用头孢哌酮舒巴坦、注射用阿奇霉素和注射用哌拉西林舒巴坦.674张处方中,不合理处方343张(占50.9％),主要类型包括临床诊断书写不全、未按照抗菌药物管理规定开具抗菌药物、适应证不适宜、遴选药品不适宜、用法与用量不适宜、无指征用药、重复给药和有不良药物相互作用.结论:我院儿科门诊抗菌药物存在不合理应用现象,应加强对抗菌药物的管理,积极发挥临床药师作用,加强医、药合作,促进临床合理用药.
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