目的：探讨布地奈德联合特布他林治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法：选择2013年2月—2015年2月赣州市人民医院收治的120慢阻肺急性加重期患者，按随机数字表法分成观察组和对照组，每组各60例。对照组患者给予特布他林单药治疗，观察组在对照组治疗的基础上联合应用布地奈德治疗，比较2组患者的疗效，各血气指标及肺功能改善情况。结果：观察组患者总有效率为96.67％（58／60），明显高于对照组的83.33％（50／60），差异有统计学意义（P＜0.05）；2组患者的二氧化碳分压、氧分压均较治疗前有明显改善，且观察组改善程度明显优于对照组，差异有统计学意义（ P＜0.05）；2组患者的肺功能均较治疗前明显改善，且观察组改善程度优于对照组，差异有统计学意义（ P＜0.05）。结论：布地奈德联合特布他林治疗慢性阻塞性肺疾病急性加重期疗效较好，可有效改善患者肺功能，改善患者临床症状。%OBJECTIVE:To probe into the clinical efficacy of budesonide combined with terbutaline in treatment of acute exacerbation of chronic obstructive pulmonary disease.METHODS:120 patients with acute exacerbation of chronic obstructive pulmonary disease admitted into Ganzhou People's Hospital from Feb.2013 to Feb.2015 were selected to be divided into observation group and control group via the random number table, with 60 cases in each.The control group were treated with single terbutaline, while the observation group additionally received budesonide based on the control group.The efficacy and the improvement of various blood acid-alkali indexes and pulmonary function were compared between two groups.RESULTS:The total effective rate of observation group was 96.67%(58/60), significantly higher than that of control group 83.33%(50/60), with statistically significant difference(P<0.05).Compared with before treatment, PaCO2 and PaO2 of both groups had been significantly improved, and the improvement of observation group was better than that of control group, with statistically significant difference( P<0.05) .Meanwhile, pulmonary function of both groups had been significantly improved, and the improvement of observation group was better than that of control group, with statistically significant difference(P<0.05).CONCLUSIONS: The efficacy of budesonide combined with terbutaline in treatment of acute exacerbation of chronic obstructive pulmonary disease is significant, which can effectively improve the pulmonary function of patients and improve the clinical symptoms.
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