目的：探讨利伐沙班对下肢静脉血栓患者血清缺氧诱导因子1α（ hypoxia inducible factor－1α，HIF－1α）、P－选择素及肿瘤坏死因子α（ tumor necrosis factors－α，TNF－α）的影响。方法：选取2015年2月—2016年2月汉川市人民医院收治的下肢静脉血栓患者120例，以随机数字表法分为观察组和对照组各60例。对照组患者实施常规治疗，观察组患者在对照组的基础上给予利伐沙班治疗。观察2组患者的治疗效果。结果：观察组患者治疗总有效率为91．67％（55／60），明显高于对照组的65．00％（39／60）；观察组患者HIF－1α、P－选择素、TNF－α表达水平均明显低于对照组，差异有统计学意义（ P＜0．05）。结论：采用利伐沙班治疗下肢静脉血栓，可缓解临床症状，降低HIF－1α、TNF－α、P－选择素表达水平，提高治疗效果。%OBJECTIVE:To probe into the effects of rivaroxaban on serum HIF-1α, P-selectin and TNF-αof patients with lower extremity venous thrombosis.METHODS: 120 patients with lower extremity venous thrombosis admitted into Hanchuan People’s Hospital from Feb.2015 to Feb.2016 were selected to be divided into observation group and control group via the random number table, with 60 cases in each.The control group were treated with conventional treatment, while the observation group additionally received rivaroxaban based on the control group.The treatment effects of two groups were observed.RESULTS: The total effective rate of observation group was 91.67%(55/60), significantly higher than that of control group [65.00%(39/60)];the level of serum HIF-1α, P-selectin and TNF-αin observation group were significantly lower than those in control group, with statistically significant difference(P<0.05).CONCLUSIONS: Rivaroxaban intreatment of lower extremity venous thrombosis can relief the clinical symptoms, decrease level of serum HIF-1α, P-selectin and TNF-αand improve the treatment effects.
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