OBJECTIVE:To investigate the preventive application of antibiotics for inguinal herniorrhaphy during perioperative period before and after the special rectification in the Second People's Hospital of Zhaoqing ( hereinafter referred to as“our hospital”) , and to provide reference for the rational drug use in clinic .METHODS:255 discharged medical records of patients with inguinal herniorrhaphy in our hospital from Jan .2012 to Dec.2014 were statistically analyzed.RESULTS:The rate of preventive application of antibiotics for inguinal herniorrhaphy was 94.12%(80/85) in 2012, 30.59%(26/85)in 2013 and falling to 17.65%(15/85)in 2014.In 2012, the categories of antibiotics used in inguinal herniorrhaphy mainly included penicillins , the second and third generation of cephalosporins and nitroimidazoles .After the special rectification , the categories selection of preventive drug use had been improved , the second generation of cephalosporins used more often than before .The combination rate of preventive application of antibiotics decreased yearly , there were no drug combinations in 2014.CONCLUSIONS:After the special rectification on clinic antibiotics use , the use rate of preventive antibiotics inguinal herniorrhaphy during perioperative period significantly decreased , which shows the significant outcome of the special rectification .It is important to formulate the matching countermeasures , strictly implement the Basic Principles for the Prevention Application of Antibiotics and the relevant regulations of the Ministry of Health , so as to improve the rationality of drug use in clinic .%目的：了解专项整治前、后肇庆市第二人民医院（以下简称“我院”）腹股沟疝修补术围术期抗菌药物预防性应用情况，为临床合理用药提供参考。方法：对我院2012年1月—2014年12月行腹股沟疝修补术患者出院病历255份进行统计分析。结果：2012年我院腹股沟疝修补术围术期抗菌药物预防性使用率为94.12％（80／85），2013年为30.59％（26／85），2014年降至17.65％（15／85）。2012年我院腹股沟疝修补术围术期预防性应用抗菌药物的品种涉及青霉素类和第2、3代头孢菌素、硝基咪唑类药物较多，专项整治后，预防性用药品种选择较前改善，第1代头孢菌素使用较多；抗菌药物预防性联合用药率逐年降低，2014年未发现联合用药情况。结论：通过抗菌药物临床应用专项整治活动，我院腹股沟疝修补术围术期抗菌药物预防性使用率明显降低，专项整治成效显著。应继续制订相应措施，严格执行《抗菌药物预防性应用的基本原则》和卫生部相关规定，提高临床用药合理性。
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