目的：了解肇庆市第二人民医院（以下简称“我院”）药品不良反应（adverse drug reaction，ADR）报告中的不合理用药情况，促进临床合理用药。方法：收集我院2010—2014年470例ADR报告，对其不合理用药情况进行审核与分析。结果与结论：470例ADR报告中，共有79例不合理用药情况，以儿童及老年患者居多。涉及药物包括抗菌药物、中药及中成药制剂、神经系统用药、调节电解质及酸碱平衡药、心血管系统用药、呼吸系统用药等6大类，其中以抗菌药物为主，其次是中药及中成药制剂。不合理用药以超剂量用药、配伍不当、无适应证用药等较为突出。应引起医药人员的高度重视，加强临床合理用药培训和指导，促进合理用药，避免不必要的ADR发生。%OBJECTIVE:To investigate the irrational drug use in the adverse drug reactions ( ADR) reports from the Second People's Hospital of Zhaoqing ( hereinafter referred to as “our hospital”) ,and to promote the rational drug use in clinic .METHODS: 470 cases of ADR reports in our hospital during 2010-2014 were collected , of which the irrational drug use would be reviewed and analyzed .RESULTS & CONCLUSIONS: Of the 470 cases, there were 79 cases of irrational drug use , the majority were children and elderly people .The involved drugs mainly included 6 types:antibiotics , TCM and Chinese patent medicine preparation , drugs of nervous system , drugs that regulate the electrolyte and acid-base imbalance , drugs for cardiovascular diseases and drugs for respiratory system; among which the majority were antibiotics , followed by Chinese patent medicine preparation . The mainly irrational drug use situations were overdose drug use , improper compatibility and no indications for drug use , etc; the medical workers should pay high attention to these phenomenon .It is necessary to strengthen the train and guidance of rational drug use for clinician and pharmacists , so as to promote the ration drug use and avoid the occurrence of unnecessary ADR .
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