目的：探讨围孕期妇女补充叶酸预防神经管畸形的效果。方法：对2004年1月至2013年9月在我院建档、检查的围孕期妇女的资料进行回顾性分析和总结，分别将不同时间段分娩的围产儿及神经管畸形儿作为对照组（2004-2008年）和观察组（2009年至2013年9月），通过对两组资料进行分析比较，了解孕期妇女补充叶酸预防神经管畸形的效果。结果：对照组发生神经管畸形9例，观察组发生2例，两组比较差异具有统计学意义（P＜0.05）。结论：围孕期妇女补充小剂量叶酸是预防神经管畸形的重要手段，可有效降低胎儿神经管畸形的发生率；应对育龄妇女加强服用叶酸的宣教。%OBJECTIVE:To investigate the preventive efficacy of periconceptional folic acid supplementation against neural tube defects. METHODS:The data of the pregnant women receiving filed and examined in our hospital from 2004 to Sept. 2013 were retrospectively analyzed and summarized. The perinatal babies and those with neural tube defects delivered at different time pe-riod were assigned to either control group(2004-2008)or observation group(2009-Sept. 2013),with the preventive efficacy of folic acid supplementation against neural tube defects evaluated through contrast analysis of the related data in the two groups. RE-SULTS:9 cases in the control group versus 2 cases in the observation group presented with neural tube defects,and the differences between the two groups were statistically significant(P<0.05). CONCLUSIONS:Periconceptional folic acid supplementation is of great importance for prevention of neural tube defects. It is important to emphasize the propaganda of folic acid supplementation in women of reproductive age.
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