OBJECTIVE: To probe into the application of fluoroquinolone antibiotics and production of imipenem-resistant Acinetobacter baumannii, so as to optimize the application in clinic. METHODS: The drug resistance rate of Acinetobacter baumannii (isolated from the specimens sent by adult inpatients) to imipenem, DDDs of fluoroquinolones and its proportion in total DDDs of antibiotics were calculated in Yichun Hospital of Integrated Traditional Chinese and Western Medicine from Jun. 2015 to Dec. 2017. Pearson correlation analysis with SPSS 16.0 software was used to analyze the correlation. RESULTS: The resistance rate of Acinetobacter baumannii to imipenem was positively correlated with the DDDs of moxifloxacin and its proportion in total DDDs of antibiotics (r=0.944, P=0.016; r=0.934, P=0.020). There was no correlation between the DDDs of levofloxacin used and its proportion in total DDDs of antibiotics and the DDDs of fluoroquinolone used and its proportion in total DDDs of antibiotics. CONCLUSIONS: The use of moxifloxacin can induce the production of Acinetobacter baumannii resistant to imipenem, and levofloxacin is preferred when clinical use of fluoroquinolone antibiotics is required.%目的:探讨氟喹诺酮类抗菌药物的使用与耐亚胺培南鲍曼不动杆菌产生的关系,优化该类药物的临床应用.方法:统计2015年7月至2017年12月宜春市中西医结合医院成人住院患者送检标本中分离出的鲍曼不动杆菌对亚胺培南的耐药率与氟喹诺酮类抗菌药物的用药频度(defined daily dose system,DDDs)及其占抗菌药物总DDDs的比例,采用SPSS 16.0软件Pearson相关分析方法,分析两者之间的相关性.结果:鲍曼不动杆菌对亚胺培南的耐药率与莫西沙星的DDDs及其占抗菌药物总DDDs的比例呈正相关(r=0.944,P=0.016;r=0.934,P=0.020),与左氧氟沙星的DDDs及其占抗菌药物总DDDs的比例和氟喹诺酮类药物的DDDs及其占抗菌药物总DDDs的比例均无相关性.结论:莫西沙星的使用可诱导耐亚胺培南鲍曼不动杆菌的产生,临床确需使用氟喹诺酮类抗菌药物时可优先考虑左氧氟沙星.
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