胆固醇7α-羟化酶（Cholesterol 7-alpha hydroxylase，CYP7A1）在维持胆固醇代谢动态平衡时起重要的作用。通过概述CYP7A1的调控机制，综述近年来报道的益生菌、膳食纤维、多酚类物质等功能性食品对CYP7A1基因表达的调节和影响，展望以CYP7A1为靶点的降胆固醇功能性食品的开发前景，旨在为筛选以CYP7A1为靶点的功能性食品提供参考。%Cholesterol 7-alpha hydroxylase (CYP7A1) have been shown to play an important role in maintaining cholesterol metabolism homeostasis. This review outlined the mechanisms underlying regulation of CYP7A1, the functional food which includes probiotics, dietary fiber and polyphenols affecting CYP7A1 and the regulation of gene expression were summarized. In addition , the development prospect of the cholesterol-lowering functional food targeting CYP7A1 was analyzed. The aim of this review was to provide clues in screening to CYP7A1 targets of functional food.
展开▼
