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Imidazole Mediated Acylation of Cholesterol in Functional Vesicles: A Simple Analogue of Lecithin: Cholesterol Acyltransferase.

机译：咪唑介导的功能性囊泡中胆固醇的酰化：卵磷脂的简单类似物：胆固醇酰基转移酶。

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Imidazole - functionalized surfactant 1 transfers acetyl groups from p-nitrophenyl acetate to cholesterol (2) in vesicular coaggregates. Acetyl surfactant 1-Ac is an intermediate, and cholesteryl acetate (3) is the product. The system mimics the human enzyme, lecithin: cholesterol acyl transferase. Here, we report that vesicles of the N,N-dihexadecylcholine ester of imidazole-4-carboxylic acid doped with cholesterol, afford 3beta-cholesteryl acetate upon reaction with p-nitrophenyl acetate (PNPA). These reactions are found to proceed via acylimidazole intermediates, and their efficiency improves above the vesicular Tc (i.e., the transition temperature above which the ordered vesicular 'gel' phase goes over to the more fluid 'liquid crystalline' phase). Keywords: Vesicles, Cholesterol, Imidazole, Acyl transfer, Imides. (kt)

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作者
Moss, R. A.; Bhattacharya, S.; Okumura, Y.;
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年度 1989
页码 1-5
总页数 5
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Cholesterol; Chemical analogs; Acetates; Acetyl chloride; Acylation; Cholesteryl esters; Enzymes; Fluids; Humans; Liquid crystals; Liquid phases; Transition temperature; Reprints; Imidazoles; Lecithin;

机译：胆固醇;化学类似物;乙酸盐;乙酰氯;酰化;胆固醇酯;酶;流体;人类;液晶;液相;转变温度;重印;咪唑;卵磷脂;

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专利

1. Molecular Mechanism of Reverse Cholesterol Transport: Reaction of Pre-beta-Migrating High-Density Lipoprotein with Plasma Lecithin/Cholesterol Acyltransferase. [J] . Fielding PE Biochemistry . 2004,第46期

机译：胆固醇逆向转运的分子机制：迁移前的高密度脂蛋白与血浆卵磷脂/胆固醇酰基转移酶的反应。
2. Cholesterol efflux by acute-phase high density lipoprotein: role of lecithin: cholesterol acyltransferase. [J] . Khovidhunkit W, Shigenaga JK, Moser AH, Journal of Lipid Research . 2001,第6期

机译：急性期高密度脂蛋白引起的胆固醇外流：卵磷脂的作用：胆固醇酰基转移酶。
3. Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase. [J] . Reshetnyak Y, Tchedre KT, Nair MP, Journal of Biomolecular Structure and Dynamics . 2006,第1期

机译：卵磷脂：胆固醇酰基转移酶的野生型和鱼眼疾病突变体之间的结构差异。
4. Soy lecithin decreases plasma total and LDL cholesterol but neither lecithin nor lupins has an effect on lean tissue or fat cholesterol levels in finisher pigs [C] . J.P.A. Sweeny, G.M. Smith, M.D. Langridge, Biennial Conference of the Australasian^Pig^Science^Association . 2013

机译：大豆卵磷脂降低了血浆总和和LDL胆固醇，但卵磷脂和羽扇蛋白都没有对硒猪的瘦组织或脂肪胆固醇水平有影响
5. EFFECTS OF TRANS- FATTY ACIDS ON TISSUE LIPIDS AND LECITHIN: CHOLESTEROL ACYLTRANSFERASE. [D] . MOORE, CAROLYN ELIZABETH. 1979

机译：脂肪酸对组织脂质和卵磷脂的影响：胆固醇酰基转移酶。
6. Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met). [O] . H G Klein, P Lohse, P H Pritchard, 1992

机译：与鱼眼综合征相关的卵磷脂-胆固醇酰基转移酶基因中的两个不同的等位基因突变。卵磷脂胆固醇酰基转移酶（Thr123 ---- Ile）和卵磷脂胆固醇酰基转移酶（Thr347 ---- Met）。
7. Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase. [O] . Wang, Kewei, Subbaiah, Papasani V 2002

机译：界面结合结构域在卵磷脂：胆固醇酰基转移酶的氧化敏感性中的作用。
8. Depression of Lecithin-Cholesterol Acyltransferase Esterification in Vitamin E-Deficient Monkeys. [R] . Mickel, H. S., Hill, P. L., Hayes, K. C. 1975

机译：维生素E缺乏猴中卵磷脂 - 胆固醇酰基转移酶酯酶的抑制作用。

Imidazole Mediated Acylation of Cholesterol in Functional Vesicles: A Simple Analogue of Lecithin: Cholesterol Acyltransferase.

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