目的：通过观察心身疾病患者脑电信号慢波δ和θ波的功率值改变,探究心身疾病“刚柔辨证”四种常见证候与脑电慢波改变的相关关系。方法“证病结合”“以方测证”为研究方法,采用脑电地形图为技术手段,把经显效方剂对应治疗2~8周后疗效为显效和临床痊愈的“刚柔辨证”主证为心肝火旺、心肝阴虚、肝郁气滞、肝郁脾虚证的患者治疗前脑电信号δ和θ波功率值与健康人对照组脑电信号δ和θ波功率值进行对照分析。其中心肝火旺证20例、心肝阴虚证32例、肝郁气滞证27例、肝郁脾虚证21例和健康人对照组23例。结果心肝阴虚证与正常人对照组比较,δ波在额区和额极区功率值增高(在FP1、F3、F4,P<0.005；在FP2,P<0.05),θ波在除了双颞区之外所有10个脑区功率值增高(P<0.005)。心肝火旺证、肝郁气滞证、肝郁脾虚证与正常人对照组比较,δ波和θ波功率值增高,以前头部为主,但此三组与对照组比较未见显著性差异。结论初步揭示“刚柔辨证”四种常见证候与脑电慢波改变的规律性及特异性表现,初步从脑电生理学角度揭示“刚柔辨证”理论的物质基础和证候实质。%Objective To explore the relationship of four common syndromes of ‘Rigid-Gentle Syndrome Differentiation’ of psychosomatic diseases and δ and θ wave change in brain electrical activity mapping ( BEAM) . Methods Syndromes are the core while diseases are the complement. The accuracy of Syndrome Differentiation has been verifying by the curative effects of fixed traditional Chinese medicine ( TCM) prescription. Each case was summarized by curative effects according to efficacy standards of different diseases. BEAM was used as technical means. Each case has been measured by BEAM before treatment. 100 cases of the four syndromes of‘Hyperactivity of heart-fire and liver-fire’ ,‘Heart and liver yin deficiency ’ , ‘Stagnation of QI due to depression of the liver ’ and ‘Stagnation of liver-QI with deficiency of the spleen ’ which belong to the system of ‘Rigid-Gentle Syndrome Differentiation ’ were enrolled in this study, and in order the number of cases are 20, 32, 27 and 21. In addition, the control group is of 23 healthy volunteers. Results The syndrome of ‘Heart and liver yin deficiency’: the rising trend of δ wave power in frontal pole and frontal region (P<0. 005 in FP1, F3, F4 and P<0. 05 in FP2) and θ wave power in ten cortical areas except double temporal region(P<0. 005). The syndrome of ‘Hy-peractivity of heart-fire and liver-fire’ ,‘Stagnation of QI due to depression of the liver’ and‘Stagnation of liver-QI with deficiency of the spleen’:the rising trend of slow wave power includingδwave andθwave in forebrain, but no significant change compared with the control group. Conclusions This study has preliminarily demonstrated the regularities and specificities of slow wave change of four common syndromes of ‘Rigid-Gentle Syndrome Differentiation ’ compared with control group in BEAM. This study has preliminarily provided the evidences of the material bases and the nature of‘Rigid-Gentle Syndrome Differ-entiation’ of psychosomatic medicine from the aspects of BEAM.
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