Objective To analyze the relationship between the diabetic nephropathy patients peripheral blood bilirubin and hemoglobin, to explore the factors inlfuencing the serum bilirubin in patients with nephropathy of diabetes. Methods This study included 106 patients with diabetic nephropathy patients, 113 cases of diabetic patients without complications and 120 healthy controls were detected in the peripheral blood, the total bilirubin, direct bilirubin, indirect bilirubin and hemoglobin content and total bilirubin and hemoglobin correlation analysis. Results Compared with the control group and diabetic group without complications, diabetic nephropathy group total bilirubin, direct bilirubin, indirect bilirubin and hemoglobin levels were signiifcantly reduced, the differences were statistically signiifcant (P<0.001);correlation analysis showed, diabetic nephropathy group total bilirubin level was positively associated with hemoglobin (r=0.455, P<0.001). Conclusion Decreased serum bilirubin in patients with diabetic nephropathy associated with the lower hemoglobin, positive correction has an important role for the treatment of anemia in patients with diabetic nephropathy.%目的：分析糖尿病肾病患者外周血胆红素水平与血红蛋白之间的关系，探讨糖尿病肾病患者血清胆红素变化的影响因素。方法研究对象包括106例糖尿病肾病患者，113例糖尿病无并发症患者和120例健康对照者，检测上述各组外周血总胆红素、直接胆红素、间接胆红素和血红蛋白含量并分析总胆红素与血红蛋白相关性。结果与对照组和糖尿病无并发症组比较，糖尿病肾病组总胆红素、直接胆红素、间接胆红素及血红蛋白水平均显著降低，差异均有统计学意义（P＜0.001）；相关分析显示，糖尿病肾病组总胆红素水平与血红蛋白呈正相关(r=0.455，P＜0.001)。结论糖尿病肾病患者血清胆红素的降低与血红蛋白降低有关，积极纠正贫血对糖尿病肾病的治疗有重要作用。
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