目的：探讨热疗联合TP方案化疗治疗中晚期非小细胞肺癌（NSCLC）的临床疗效、生活质量改善率和毒副反应。方法40例入组的ⅢB期或Ⅳ期NSCLC患者，随机分为对照组（20例）和治疗组（20例），治疗组采用热疗联合TP方案化疗2周期，对照组仅行TP方案化疗2周期，比较两组间临床疗效、生活质量改善及毒副反应的差异。结果治疗组和对照组的有效率分别为65%和35%，差异有统计学意义（P＜0.05）；两组患者间生活质量改善率的差异有统计学意义（P＜0.05）；两组间毒副反应的差异无统计学意义（P＞0.05）。结论热疗联合化疗治疗中晚期NSCLC疗效确切，生活质量明显改善，毒副反应可以耐受，值得临床推广应用。%Objective To investigate the clinical efifcacy, the change of KPS scores and side effects induced by thermotherapy combined with TP chemotherapy in treating patients with advanced non-small cell lung cancer(NSCLC).Methods Forty cases with NSCLC stageⅢB orⅣ were enrolled in this study, they were randomly divided into two groups. The observation group (n=20) was treated with paclitaxel plus cisplatin (TP) for two cycles, combined with thermotherapy. The control group (n=20) was treated only with regular TP chemotherapy for two cycles. The clinical efifcacy, the change of karnofsky (KPS) scores and side effects were compared between the two groups.Results The response rate in observation group was 65%, and 35% in control group. There was signiifcant difference between two groups (P<0.05). The difference was signiifcant in the change of KPS score before and after treatment between two groups (P<0.05). The toxic and side effects of the two groups had no signiifcant difference (P>0.05).Conclusion Thermotherapy combined with TP chemotherapy can increase efifcacy and improve life quality of the patients with advanced NSCLC, and the toxicity can be tolerated, it was worthy for clinical use.
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