Objective To determine the effects of curcumin on anti‐oxidation and serum lipid in apoE-/- mice . Method ApoE-/- mice were fed a high‐fat diet for 8 weeks and treated with various dosage (low ,median ,high:50 , 100 ,200 mg/kg body weight/day) for additional 4 ,8 or 12 weeks .The serum and livers were obtained and the SOD ,CAT ,MDA and serum lipid levels were detected .Result The changes in SOD ,CAT and MDA both in serum and livers were dependent on the increase of curcumin dosage .The serum lipid level including total cholesterol (TC) ,triglyceride (TG)and low density lipoprotein‐cholesterol (LDL‐C) also showed the same tendency .The in‐creasing of SOD and CAT activities and decrease of MDA that there were statistical significantly differences com‐pared with untreated control group at median dose (P<0 .05) ,while the level of TC ,TG and LDL‐C were signifi‐cantly decreased only when treated with high doge (P<0 .05) .Conclusion Curcumin has a function of anti‐oxidation and lowing serum lipid in the atherosclerosis mode apoE-/- mice induced by high fat diet .%目的：探讨姜黄素在小鼠体内抗氧化能力和血脂代谢中的作用。方法高脂饮食诱导基因敲除的apoE－／－小鼠8周之后，用不同剂量（50、100、200 mg／kg 体质量）的姜黄素连续灌胃4周、8周或12周。获取血清和肝脏并分别检测各种抗氧化指标和各项血脂含量。结果血清和肝脏的SOD和CAT的活性、MDA含量的变化均随剂量的升高而表现得更加明显；各项血脂指标降低，也表现出剂量的依赖性。其中在中剂量时SOD和CAT的活性的升高、MDA含量的下降均能达到显著差异（P＜0．05），而各项血脂指标包括总胆固醇、甘油三脂和低密度脂蛋白胆固醇只有在高剂量时才表现出显著下降（P＜0．05）。结论姜黄素对于高脂诱导的动脉粥样硬化小鼠具有抗氧化，降低血脂的作用。
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