目的 探讨抗磷脂抗体综合征、血栓前状态与早发型重度子痫前期发病之前的相关性,寻找早期诊断早发型重度子痫前期的指标.方法 收集我院住院分娩的早发型(早发组)及晚发型重度子痫前期患者(晚发组)各70例.同时随机选取70例同期入院的正常孕妇为对照组.对比各组患者外周血甘油三脂(TG)、胆固醇(TC)、出凝血功能指标以及血清抗心磷脂抗体、抗β2-GPI抗体等表达水平.结果 三组间出凝血功能对比中,早发组抗凝血酶(AT)活性显著低于晚发组及正常对照组,差异均有统计学意义(P＜0.05).三组TC、TG及D-二聚体对比中,早发组D-二聚体平均秩次为76.6 mg/L,显著高于晚发组的58.3 mg/L和正常组的54.1 mg/L,差异均具有统计学意义(P＜0.05).早发组抗ACA抗体阳性率及抗β2-GPI抗体阳性率显著高于晚发组及正常组,差异有统计学意义(P＜0.05).结论 抗凝血酶、D-二聚体、抗ACA抗体阳性率及抗&-GPI抗体可作为早期诊断早发型重度子痫前期的指标.%Objective To study the correlation of antiphospholipid antibody syndrome,prethrombotic state with the incidence of early onset severe preeclampsia,and to investigate the indexes for the early diagnosis of early onset severe preeclampsia.Methods Puerperants in our hospital with early onset severe preeclampsia (the early group,n=70) and late onset severe preeclampsia (the late group,n=70) were collected.At the same time,70 normal pregnant women were randomly selected as the control group.The three groups were compared in glycerol three fat (TG),cholesterol (TC),coagulation index and serum anticardiolipin antibody,anti-β2-GPI antibody levels.Results For coagulation index,the antithrombin (AT) activity in the early group was significantly lower than that in the late group and the control group (P＜0.05).For TC,TG and D-dimer,the D-dimer average rank was 76.6 in the early group,significantly higher than 58.3 in the late-onset group and 54.1 in the control group (P＜0.05).The positive rates of ACA antibody and anti-β2-GPI antibody in the early group was significantly higher than those in the late group and the control group (P＜0.05).Conclusion Antithrombin,D-dimer,the positive rate of ACA antibody and anti-β2-GPI antibody can be used as the indexes for the early diagnosis of early onset severe preeclampsia.
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