Objective:To compare the clinical effect of telbivudine and lamivudine in the treatment of chronic hepatitis B.Methods:68 cases with chronic hepatitis B were randomly divided into telbivudine treatment group (group A)and lamivudine treatment group (group B),each group had 34 cases,observed the complete response rate,HBeAg negative rate and recovery rate of ALT after treatment in two groups.Results:after 2 years treatment the complete response rate, HBeAg negative conversion rate and the recovery rate of ALT of cases in observation group were higher than that in control group,there was significant difference between two groups (P<0.05).Conclusions:Clinical effect of telbivudine in treatment of chronic hepatitis B is superior to lamivudine,should be further pro-moted in clinical using.%目的：比较替比夫定与拉米夫定治疗慢性乙型肝炎的疗效。方法：将符合慢性乙型肝炎诊断标准的68例慢性乙型肝炎患者按照随机对照原则分为替比夫定治疗组（A组）和拉米夫定治疗组（B组），每组各34例，随访观察两组患者治疗后的完全应答率、HBeAg转阴率以及ALT复常率。结果：治疗2年后观察组患者的完全应答率、HBeAg转阴率以及ALT复常率均高于对照组患者，组间差异有统计学意义（P＜0．05）。结论：替比夫定治疗慢性乙型肝炎的疗效优于拉米夫定，应在临床进一步推广使用。
展开▼
