孕激素除了参与生殖功能外，作为神经甾体可以通过不同的途径对中枢神经系统发挥快速调节作用，与炎症防护因子如TNF-α和1L-1β及生长因子的表达、神经递质、海马突触传递和突触可塑性有着密切关系。孕激素在产后抑郁症的作用研究中呈现出复杂性和多重性，其作用机制还不是很清楚，有待进一步研究。文章就孕激素的合成与受体、对产后抑郁症中所起的作用及其作用机制进行综述。%In addition to its contribution to the process of reproduction, progesterone as a neurosteroid also influence the function of the central nervous system through various approaches.A close correlation has been found between progesterone and the expression of inflammation protective factors ( e.g. TNF-alpha and 1L-1 beta ) and growth factors, neurotransmitters, synaptic transmission and synaptic plasticity.However, the mechanism in which progesterone contributes to the process of postpartum depression is complicated and sophisticated and therefore needs to be explicated.The study attempts to obtain a profound and clear understanding of the mechanism through a comprehensive review of the researches into the problem.
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