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首页> 外文期刊>Journal of obstetrics and gynaecology: the journal of the Institute of Obstetrics and Gynaecology >The benefit of oestrogens and progestogens in postnatal depression.
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The benefit of oestrogens and progestogens in postnatal depression.

机译：雌激素和孕激素对产后抑郁症的益处。

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摘要

Postnatal depression, with a prevalence of at least 10%, is a common complication of the puerperium. The aetiology is unclear, specific diagnostic criteria cannot be drawn and the treatment options are limited. As hormones are thought to contribute to its pathophysiology, the supplementation with either progesterone or oestrogen might be of prophylactic and/or therapeutic value in postnatal depression. Research into hormonal prophylaxis and treatment of postnatal depression (PND) is limited. This review article is aimed at exploring the evidence available regarding the use of oestrogen and progesterone in postnatal depression. A search of electronic databases Medline, Psychinfo, Embase and published books from 1970 to 2002 was carried out. The search strategy was limited to the English language. Of 193 articles, 30 were chosen and all 30 copies were identified and analysed critically. Prophylactic and treatment value were separately analysed for both oestrogen and progesterone. Some uncontrolled studies by Dalton (1982, 1985) report the benefit of progesterone in preventing postnatal depression. The value of oestrogen in preventing and treating this disorder is suggested by some articles but the methodological shortcomings in these studies make the study results unreliable. In addition, the use of oestrogen in the postnatal period may have significant side effects. Use of synthetic progesterone is associated with depression in the postnatal period and should be used with caution. Oestrogen therapy may be of modest value in severe postnatal depression.
机译：产后抑郁症的患病率至少为10％，是产褥期的常见并发症。病因尚不清楚，无法制定具体的诊断标准，治疗选择有限。由于人们认为激素有助于其病理生理，因此补充孕酮或雌激素可能对产后抑郁症具有预防和/或治疗价值。激素预防和治疗产后抑郁症（PND）的研究有限。这篇综述文章旨在探讨有关在产后抑郁症中使用雌激素和孕酮的现有证据。检索了1970年至2002年的电子数据库Medline，Psychinfo，Embase和已出版的书籍。搜索策略仅限于英语。在193篇文章中，选择了30篇，并对所有30篇文章进行了鉴定和分析。分别分析了雌激素和孕激素的预防和治疗价值。道尔顿（1982，1985）进行的一些未经控制的研究报告了孕酮在预防产后抑郁中的益处。一些文章提出了雌激素在预防和治疗这种疾病中的价值，但是这些研究的方法学缺陷使得研究结果不可靠。此外，在产后使用雌激素可能会产生明显的副作用。出生后使用合成孕酮会导致抑郁，应谨慎使用。严重的产后抑郁症中雌激素治疗可能价值不高。

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