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血清白蛋白与压疮相关性的循证评价

     

摘要

Objective To find out the possible correlation between serum albumin and pressure ulcer and provide evidence for the selection of pressure ulcer risk assessment indicators .Method The Cochrane Library, Embase, Pubmed, CMB, CNKI, VIP and WanFang were searched for relevant previous studies .The included studies were confirmed according to the inclusion and exclusion criteria .The Rev man 4.2 was used for data analysis .Finding Thirteen studies ( included 2142 patients) met the inclusion criteria .Meta analysis results showed albumin in patients with and without pressure ulcers were significantly different(WMD:-0.35, 95%CI:-0.49,-0.20).Subgroup analysis indicated that the research object might be the sources of heterogeneity .Sensitivity analysis showed that the results were stable .Funnel flot and Fail-safe number showed that the publication bias was small .Conclusion Serum albumin is correlated to pressure ulcer .We suggest that serum albumin instead of appetite and other nutrition should be used as the evaluation indicators for pressure ulcer prediction .%目的:明确血清白蛋白水平与压疮发生的相关性,为压疮风险评估指标的选择提供证据支持。方法计算机检索Cochrane library, EmBase, Pubmed, CBM, CNKI, VIP和WanFang数据库。根据纳入和排除标准对检索出的文献进行筛选、确定纳入文献。采用Revman4.2软件对数据进行统计分析。结果共纳入13个研究,包括患者2142人。 Meta分析结果显示压疮组白蛋白水平与非压疮组比较差异有统计学意义( WMD:-0.35,95%CI:-0.49,-0.20)。亚组分析发现研究对象不同可能为异质性来源。敏感性分析表明结果稳定性较好,漏斗图和失安全系数计算均提示发表偏倚的影响较小。结论血清白蛋白水平与压疮发生相关,建议以血清白蛋白水平替代食欲等主观营养评价条目,提高压疮评估量表的预测能力。

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