Objective To investigate the diagnostic value of serum levels of angiopoietin-like protein 2 (ANGPTL2) and Des-γ-carboxy prothrombin (DCP) in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods A total of 98 patients with HBV-related HCC who were admitted and teated in our hospital from January 2014 to December 2016 were enrolled as HCC group,and the other 87 patients with HBV-related cirrhosis were enrolled as cirrhosis group,moreover,the 61 patients with chronic hepatitis B were enrolled as CHB group. The general condition and laboratory indexes were recorded,and the serum levels of AFP,ANGPTL2 andDCP were detected,moreover, the diagnostic efficiency of ANGPTL2 and DCP for HBV-related HCC was analyzed by means of ROC curve.Results The serum levels of ANGPTL2 in HCC group [(2.76 ± 0.94)log10pg/L] were higher than those in cirrhosis group [(1.81 ± 0.60)log10pg/L] and CHB group [(1.48 ± 0.63)log10pg/L].The serum levels of DCP in HCC group [(13.78 ± 5.70)μg/L] were higher than those in cirrhosis group [(8.62 ± 4.62)μg/L] and CHB group [(4.91 ± 3.02)μg/L].The levels of ANGPTL2 in HCC group were closely positively correlated with AFP (r=0.452,P<0.01), DCP (r=0.214,P<0.05) and clinical stage (r =0.489,P<0.01).Moreover DCP was closely positively correlated with AFP (r=0.241,P<0.05) and clinical stage (r=0.489,P<0.01).The AUC of simple ANGPTL2 in differential diagnosis between HCC and cirrhosis was 0.786 (95% CI:0.716~0.855),and which in DCP was 0.756 (95% CI:0.687~0.825),and the AUC of ABGPTL2 combined with DCP as well as AFP was 0.859 (95% CI:0.802 ~0.917). Conclusion The serum levels of ANGPTL2 and DCP are obviously increased in patients with HBV-related HCC,moreover,which are correlated to clinical stage,and combination detection of ANGPTL2,DCP with AFP can enhance the diagnosis efficiency for HCC.%目的 探讨血清血管生成素样蛋白2(ANGPTL2)及脱-γ-羧基凝血酶原(DCP)用于慢性乙型肝炎病毒(HBV)相关肝细胞癌(HCC)诊断的临床价值.方法 纳入住院的HCC患者98例(HCC组),同时纳入HBV相关肝硬化患者87例(肝硬化组)及慢性乙型肝炎患者61例(CHB组).记录患者一般情况及实验室指标,检测血清甲胎蛋白(AFP)、ANGPTL2及DCP;分析ANGPTL2及DCP与各项指标的相关性,ROC曲线分析诊断性能.结果 HCC组血清ANGPTL2水平显著高于肝硬化组及CHB组;HCC组DCP也显著高于肝硬化组及CHB组.HCC组中,ANGPTL2与AFP(r=0.452,P<0.01)、DCP(r=0.214,P=0.035)及临床分期(r=0.409,P<0.01)呈显著正相关;DCP与AFP (r=0.241,P=0.017)及临床分期(r=0.489,P<0.01)也呈显著正相关.ANGPTL2单独区别诊断HCC与肝硬化的AUC为0.786(95% CI为0.716~0.855),DCP的AUC为0.756(95% CI为0.687~0.825);AANGPTL2、DCP及AFP联合的AUC为0.859(95% CI为0.802~0.917).结论 HCC患者血清ANGPTL2及DCP存在显著升高且与临床分期相关,ANGPTL2、DCP及AFP联合用于诊断HCC的价值较高.
展开▼
