目的：检测辛伐他汀片在4种溶出介质中的不同时间的溶出度，绘制溶出曲线，确定溶出介质，建立溶出度检测方法。方法：在不同的溶出介质中，分别在5、10、15、20、30、40分钟取样，测定溶出度，绘制出溶出曲线，比较在不同介质中的溶出结果。结果：最终选择含0.5%十二烷基硫酸钠的0.01mol/L磷酸二氢钠缓冲液为溶出介质。结论：辛伐他汀片在不同溶出介质中的溶出度与其自身理化性质有直接关系。%Objective:Detecting Simvastatin Tablets dissolution of the different times in the four kinds of dissolution medium, draw-ing the dissolution curve, to determine the dissolution medium, the establishment of the detection method of the dissolution. Methods:Different dissolution media, 5,10,15,20,30,40 minute sampling measured dissolution dissolution curve plotted comparative dissolution re-sults in different media.Results:Eventually containing 0.5%sodium dodecylsulfate 0.01mol/L sodium dihydrogen phosphate buffer dis-solution medium. Conclusion:Dissolution of simvastatin tablets in different dissolution media have a direct relationship to its physico-chemical properties.
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