AIM:To observe the effects of using 0.1g/L mitomycin-C ( MMC ) to prevent the formation of haze in laser-assisted subepithelial keratomileusis ( LASEK ) for moderate and high myopia. METHODS:Totally 78 cases (156 eyes) were randomly divided into two groups.With group MMC including 86 eyes, 0.1g/L MMC and balanced salt solution ( BSS ) within sponges dip the ablated zone; The control group (70 eyes) used BBS in the same way.Uncorrected visual acuity ( UCVA), corneal epithelial healing time, and the formation of corneal haze 1, 3, 5 and 7d; 2wk; 1,3 and 6mo after surgery were observed. RESULTS: The incidence of haze of group MMC was lower than the control group, the difference was statistically significant ( P0.05). CONCLUSION: The application of 0.1g/L MMC during LASEK can prevent the formation of haze.%目的：观察中高度近视在准分子激光上皮下角膜磨镶术（laser-assisted subepithelial keratomileusis ，LASEK）中应用0．1g/L丝裂霉素（ mitomycin-C，MMC）抑制术后角膜上皮下雾状混浊（ haze ）的疗效。 方法：对78例156眼患者行LASEK，随机分成MMC组（86眼）及对照组（70眼），术中两组分别采用含0．1g/L MMC与平衡盐溶液（ BSS ）的吸水棉签点蘸激光切削后的基质床。观察患者术后1，3，5，7 d；2 wk；1，3，6 mo的症状，裸眼视力，角膜上皮愈合时间及haze形成情况。 结果：术后MMC组haze发生率低于对照组，两组haze形成差异有统计学意义（P＜0．05）；术后角膜上皮愈合时间及裸眼视力均无明显差异。 结论：LASEK术中点蘸法应用0．1g/L MMC可抑制haze的形成。
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