目的:探讨小泛素相关修饰物(small ubiquitin-related modifier,SUMO)特异性蛋白酶1(SUMO specific protease 1,SENP1)和ERα在Ⅰ型子宫内膜癌中的表达,并分析两者之间的相互关系.方法:收集Ⅰ型子宫内膜癌组织及其配对癌旁组织各50例,采用免疫组织化学法检测SENP1蛋白及雌激素受体(ERα)的表达,分析其表达与患者临床病理参数的关系.结果:Ⅰ型子宫内膜癌中SENP1蛋白在癌旁组织中的表达明显高于肿瘤组织.SENP1蛋白在高分化肿瘤中的表达明显高于低分化肿瘤组织.SENP1阳性表达与ERa表达呈正相关,而与患者的年龄、肿瘤浸润的深度、肿瘤分期及淋巴结转移无关.结论:SENP1在Ⅰ型子宫内膜癌的发生、发展中发挥重要作用,有望成为治疗子宫内膜癌的新靶点.%Objective:To investigate the expression and relationship of SUMO specific protease 1 (SENP1) and ERa in type-1 endometrial carcinoma.Methods:Fifty endometrial cancer cases were involved in this study.Immunohistochemical method was performed to study SENP1 protein and estrogen receptor (ER) expression in endometrial cancer tissues and para-carcinoma tissues.Correlations between SENP1 and ERα,as well as clinical pathological parameters were also analyzed.Results:Expression of SENP1 protein in type-1 endometrial carcinoma was significantly higher than that in the para-cancer tissues.Expression of SENP1 protein was significantly higher in well-differentiated tumors than in poorly-differentiated tumors.Expression of SENP1 was positively correlated with the expression of ERα,but not with the age of patients,the depth of tumor invasion,tumor stage and lymph node metastasis.Conclusion:SENP1 may play an important role in the occurrence and development of type-1 endometrial carcinoma,which may be a new target for the treatment of endometrial carcinoma.
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