The transdifferentiation of epithelial cells into motile mesenchymal cells was known as epithelial-mesenchymal transition (EMT). This switch in cell behavior has been illustrated to be mediated and closely related by some key transcription factors, including SNAIL, zinc-ifnger E-box-binding (ZEB) and basic helix–loop–helix transcription factors (TWIST). This article reviewed the research of recent progress of transcription factors the related mechanism of EMT.%上皮细胞-间充质转化(epithelia-mesenchymal transition,EMT),是指上皮细胞通过特定程序转化为具有间质表型细胞的生物学过程,目前研究证实这种表型的转化与转录因子密不可分.与其他转录因子相比,转录因子SNAIL、TWIST、ZEB为促进EMT过程的主要转录因子,本文总结国内外与EMT相关研究并对转录因子及其在EMT过程中的分子机制加以综述.
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