Objective:To investigate the clinical and pathological features, cause, diagnosis and differential diagnosis and treatment of giant cell reparative granuloma. Methods:Retrospective analysis of the clinical data was conducted in one case of giant cell reparative granuloma, and the histopathological morphology, imaging features, and related literatures. Results:US displayed low echo mass, CT displayed nonspeciifc osteolytic damage, enhanced MR lesions showed moderate degree of inhomogeneous enhancement. Giant cell reparative granuloma had a proliferation of spindle ifbroblasts, interstitial hemorrhage. Multinucleate giant cells of different sizes distributes irregularly. Conclusion:Giant cell reparative granuloma is uncommon nonneoplastic lesion that arises in sellar area is rare. It is usually misdiagnosed for a giant cell tumor. Diagnosis of GCRG is based on clinical information, imaging features, pathological features and response to treatment of the disease. Complete surgical resection is seen as the most suitable treatment for GCRG.%目的：探讨鞍区巨细胞修复性肉芽肿(giant cell reparative granuloma，GCRG)的临床病理特征、病因、诊断、鉴别诊断及治疗。方法：回顾性分析1例鞍区巨细胞修复性肉芽肿患者的临床、影像学及病理学结果，并回顾相关文献。结果：B超表现为边界尚清楚的低回声肿物，CT表现为非特异性骨质破坏，MRI表现为中等度不均匀强化的占位性病变。镜下检查：病变见梭形成纤维细胞增生，富含多核巨细胞，大小不一，分布不规则，间质可见出血。结论：巨细胞修复性肉芽肿是一种罕见的非肿瘤性良性病变，易误诊为骨巨细胞瘤，对巨细胞修复性肉芽肿应结合临床、影像学、病理学及对治疗的反应做出诊断；手术彻底切除病灶是目前最有效的方法。
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