各种原因造成的大段骨缺损的修复是临床极为棘手的问题，近年来组织工程化骨的研究发展为口腔颅颌面部骨缺损开辟了新的解决途径。生长因子是骨组织工程中的三大要素之一，目前已经发现多种细胞因子对成骨过程具有重要的调节作用。与颅颌面发育密切相关的尼尔样-1型生长因子(NELL-1)对成骨细胞系有高度的特异性，可在多种模型内成功诱导成骨，且无骨形态发生蛋白-2的异位肌内成骨的缺点。本文就 NELL-1基因及其蛋白， NELL-1基因在成骨分化中的作用和相关分子信号途径， NELL-1生长因子在颅颌面部组织工程骨再生中的作用等研究进展作一综述。%There are often various causes of bone defects in clinics. A new approach has been put forward in recent years to settle the problem, which is bone tissue engineering. Novel osteospecific growth factors are very important to the bone tissue engineering, because of the efforts to enhance bone regeneration. Nel-like type 1 (NELL-1)growth factor, a potent growth factor associated with craniosynostosis, is highly specific to the osteo-chondral lineage, and has demonstrated induction of bone in multiple in various models. And unlike bone mor-phogenetic protein-2, NELL-1 growth factor cannot initiate ectopic bone formation in muscle. This review summa-rized the studies on NELL-1 growth factor that had relevance to bone tissue engineering, especially in craniomax-illofacial filed.
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