Matrix metalloproteinases (MMP) are a family of proteolytic enzymes with the main function of hy-drolyzing extracellular matrix, of which activity requires calcium and zinc ions. The acidic component of dentin adhesives can activate the pro-MMP to degrade the nude collagen fibrils and destroy the interface of resin-dentin bond which leads to the failure of binding. Inhibiting MMP will increase bond durability. The purpose of this article is to review the research progress of MMP's activating in resin-dentin bond and influence on bond durability, special attention being devoted to the means to inhibiting or inactivating MMP.%基质金属蛋白酶(MMP)是一组分解细胞外基质的钙锌离子依赖型蛋白酶的总称.牙本质粘接剂酸性环境可以激活MMP酶原,进而分解暴露的胶原纤维,破坏粘接界面而导致粘接的失败.抑制MMP可有效增加粘接耐久性.本文就MMP在粘接过程中的激活和对粘接耐久性的影响以及MMP抑制剂的研究进展作一综述.
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