Objective To probe into the effectiveness and safety of Gatifloxacin Mesylate Injection in the treatment of acute urinary tract infections. Methods A total of 126 cases patients, who were diagnosed as acute urinary tract infection, were at random divided into experimental group of 63 cases and control group of 63 cases. The Gatifloxacin Mesylate Injection was used in experimental group by intravenous drip, 400mg a time and 1 times daily; the Levofloxacin Hydrochloride Injection was used in control group by intra-venous drip, 200mg a time and 2 times daily, in which the course of treatment was 7 to 14 days. Results Of the experimental group and control group, the cure rates were respectively 79.36% and 68.25%; rates of effectiveness respectively 92.06% and 80.95%; and rates of bacterium elimination respectively 93.65% and 82.54% (P>0.05). The rates of harmful reaction for experimental group and control group were respectively 3.17% and 4.76%, in which the experimental group was slighter than that in control group. The follow-up rate of recurance in experimental group was lower than that in control group, P<0.05. Conclusion The effect of Gatifloxacin Mesylate Injection and Levofloxacin Hydrochloride Injection in the treatment of acute urinary tract infections is equal, but the harmful reaction is less and tolerance is better for Gatifloxacin Mesylate Injection against Levofloxacin Hydrochlo-ride Injection.%目的 探讨甲磺酸加替沙星注射液治疗急性尿路感染的有效性和安全性.方法 将临床确诊为急性尿路感染的患者126例随机分为试验组和对照组,各63例,试验组给予甲磺酸加替沙星注射液(Gatifloxacin Mesylate Injection)400mg,静脉滴注,每日1次;对照组给予盐酸左氧氟沙星注射液(Levofloxacin Hydrochloride Injection)200mg,静脉滴注,每日2次,疗程7～14d.结果 甲磺酸加替沙星组与盐酸左氧氟沙星组痊愈率分别为79.36%与68.25%;有效率分别为92.06%与80.95%;细菌清除率分别为93.65%与82.54%.两组比较,P＞0.05.不良反应发生率分别为3.17%与4.76%,不良反应较轻.随访复发率试验组低于对照组,P＜0.05.结论 甲磺酸加替沙星注射液治疗急性尿路感染与盐酸左氧氟沙星注射液效果相当,不良反应较少,耐受性好.
展开▼
