Objective To investigate the clinical efficacy of N-acetylcysteine (NAC) in the treatment of chronic obstructive pulmonary disease(COPD)complicated with idiopathic pulmonary fibrosis(IPF). Methods A total of 142 patients who were COPD complicated with IPF were enrolled and randomly assigned to the two treatment regimens ,the control group treated with conven-tional treatment aminophylline tablets,ambroxol hydrochloride tablets,the observation group treated with NAC,Then observe the therapeutic effect of the two groups. Results C-reactive protein (CRP) in the observation group lower than control group(P<0.05);The forced expiratory volume in one second(FEV1),vital capacity(VC),diffusion capacity for carbon monoxide of the lung (DL-CO),PaO2 and transforming growth factor(TGF)-β1 in the observation group better than control group (P<0.05);observation group total effective rate 83.10%,significantly higher than the control group 59.15% (P<0.05). Conclusion NAC can inhibit the devel-opment of fibrosis in COPD complicated with IPF patients,improve the lung function and PaO2 levels.%目的：探讨N-乙酰半胱氨酸治疗慢性阻塞性肺疾病（COPD）合并肺间质纤维化（IPF）的疗效。方法将142例COPD合并IPF患者随机均分为观察组和对照组，对照组给予氨茶碱片、盐酸氨溴索片等常规治疗，观察组加用N-乙酰半胱氨酸治疗，观察两组治疗效果。结果观察组治疗后CRP评分低于对照组（P＜0.05）；观察组患者治疗后FEV1、VC、DLCO、PaO2及TGF-β1优于对照组（P＜0.05）；观察组治疗总有效率为83.10%，明显高于对照组的59.15%（P＜0.05）。结论 N-乙酰半胱氨酸可抑制COPD合并IPF患者肺纤维化，改善肺功能及PaO2水平。
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