Objective To study the effect of Zhilong Huoxue Tongyu capsules on serum content of fibrinogen (Fib) and homocysteine (Hcy) in patients with carotid artery stenosis. Methods a total of 144 patients with carotid stenosis confirmed by carotid artery color Doppler ultrasound were enrolled in the Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University from 2014 June to 2015 June, of which 60 cases of mild stenosis, 60 cases of moderate stenosis, 24 cases of severe stenosis , according to the ratio of 1:1 were randomly divided into Zhilong Huoxue Tongyu capsules observation group and aspirin group, and both two groups were given life style intervention,atorvastatin calcium and basic disease treatment. In addition, the Zhilong observing group was treated with Zhilong Huoxue Tongyu capsules (1.2g tid. Po.), and the Aspirin control group was given Aspirin tablet (100mg qd. Po.).The whole treatment process lasted for 1 year. The differences of impact from Zhilong Huoxue Tongyu capsules and Aspirin were observed on Fib and Hcy content of patients with different degrees of carotid artery stenosis. Results After treatment, the Hcy contente of observation group and the control group were both reduced by varying degrees (P <0.05). Among the subgroups, the mild and moderate stenosis groups their Hcy content decrease was significantly lower than the control group (P <0.05). After treatment all groups showed positive change in Fib when compared to before treatment (P <0.05), There was no significant difference in Fib between observation group and the control group (P >0.05). Conclusion 1) Zhilong Huoxue Tongyu capsule can reduce the serum Hcy and Fib content of patients with carotid artery stenosis; 2) For patients with mild and moderate stenosis of carotid artery, Zhilong Huoxue Tongyu capsules had a better effect of reducing serum Hcy than Aspirin.%目的 观察蛭龙活血通瘀胶囊对颈动脉狭窄患者血清同型半胱氨酸(Hcy)及纤维蛋白原(Fib)的影响.方法 纳入2014年6月-2015年6月在西南医科大学附属中医医院就诊、经颈动脉彩色超声证实为颈动脉狭窄的患者144例,轻度狭窄60例,中度狭窄60例,重度狭窄24例,按1:1简单随机分为蛭龙活血通瘀胶囊观察组和阿司匹林对照组,2组均给予生活方式干预、阿托伐他汀钙及基础疾病治疗,观察组给予蛭龙活血通瘀胶囊1.2 g,3次/d口服,对照组给予阿司匹林肠溶片100 mg,1次/d口服.疗程1年.观察蛭龙活血通瘀胶囊与阿司匹林对不同程度颈动脉狭窄患者的Fib及Hcy值的影响.结果 Hcy:治疗后,观察组和对照组Hcy值较治疗前均有不同程度降低(P<0.05).其中,在颈动脉轻度及中度狭窄亚组中,观察组Hcy值降低较对照组更为明显(P<0.05).Fib:治疗后,观察组和对照组Fib值较治疗前均有不同程度降低(P<0.05).2组间比较,差异无统计学意义(P>0.05).结论 1)蛭龙活血通瘀胶囊能够降低颈动脉狭窄患者血清中Hcy和Fib值;2)在颈动脉轻度、中度狭窄患者中,蛭龙活血通瘀胶囊改善Hcy的作用优于阿司匹林.
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