[ Objective ] The aim was to observe the control effect of perilla seed extracts (EPS) on the hyperlipidemia of rabbits. [ Method ] The high fat and cholesterol diet were adopted to build the hyperlipidemia model of rabbit. The rabbits were randomly and equally divided into 5 groups which were NC (normal control) group, HLM(high lipid model) group, EPSⅠ, EPSⅡ and EPS Ⅲ group (low, middle, high dose of 0.1 g/ml,0.5 g/ml and 1.0 g/ml EPS respectively). The contents of TC, TG, LDL-C and HDL-C in serum and the contents of MDA, the activity of SOD in liver homogenate were detected respectively. [ Result ] The EPS groups could significantly decrease the contents of TC, TG and LDL-C and improve the contents of HDL-C; reduce the contents of MDA and improve the activity of SOD. [ Conclusion ] EPS could regulate blood fat and control act lipid peroxidation.%[目的]研究苏子提取物(EPS)对家兔高脂血症的防治作用.[方法]采用高脂饮食建立家兔高脂血症模型,分别测定正常对照组,高脂模型组,苏子提取物低剂量组(0.1g/ml)、中剂量组(0.5g/ml)、高剂量组(1.0 g/ml)血清中的TC、TG、LDL-C、HDL-C及肝匀浆MDA 含量及SOD 活性.[结果]EPS能显著降低血清中的TC、TG、LDL-C,提高血清中HDL-C的含量,降低肝匀浆MDA的含量,提高SOD的活性.[结论]EPS 具有一定的调节血脂及抗脂质过氧化作用.
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