[Objective]The aim was to research the relationships between the side chain of maleic anhydride structure compounds and inhibition effect on Aspergillus niger. [Method]Choosing 7 kinds of common compounds with maleic anhydride structure and tautomycin, the test of inhibiting Aspergillus niger was carried out by using oxford cup method. [Result]Diphenylmaleic anhydride with the concentration of 10 g/L had a good inhibition on Aspergillus niger, while tautomycin with the lower concentration of 1 g/L also had a considerable inhibition effect. [Conclusions]The side chain of maleic anhydride structure compounds containing chlorine could promote the inhibition effect on Aspergillus niger, and containing benzene couldn't enhance the activity of inhibition on Aspergillus niger.%[目的]研究含顺丁烯二酸酐结构化合物侧链结构与抑制黑曲霉效果的关系. [方法]选取7种常见含顺丁烯二酸酐结构化合物以及变构霉素,用牛津杯法进行抑制黑曲霉试验.[结果]3, 6-二氯邻苯二甲酸酐在10 g/L浓度下对黑曲霉有较好的抑制作用,变构霉素在1 g/L 浓度下仍对黑曲霉有一定的抑制作用. [结论]含顺丁烯二酸酐结构化合物侧链含有氯对抑制黑曲霉有促进作用,而含有苯环则不能增强其对抑制黑曲霉的活性.
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