(Z) -N-( cyclooct-2-enyl) -N-p-tolylacrylamide was synthesized by cyclooctene, 4 -Toluidine, NBS, acrylic acid and PCl5. Then this paper focused on the Pd-catalyzed Domino[l5] cyclization of the substrate with 4-Bromo-1, 2-( Methylenedioxy) benzene via C-H activation. A novel isoindole derivatives was prepared through one-pot method with high effectively and regioselectivity under mild condition. The yield of the reaction is about 70%. The structure of the compound was confirmed by IR, 1HNMR, 13CNMR, MS and X-ray diffraction.%以环辛烯、对甲基苯胺、N-溴代丁二酰亚胺（NBS)、丙烯酸、五氯化磷为初始原料合成N-丙烯酰基-N-（2-环辛烯)对甲基苯胺,主要研究了钯催化下该底物与4-溴-1,2-亚甲二氧基苯的C-H活化Domino环化反应。在温和条件下高效、高选择性一锅法合成了一种异吲哚衍生物产率为70%。通过IR,1 HNMR,13 CNMR,MS对目标产物的结构进行了表征,并用X-射线单晶衍射仪测得其晶体结构。
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