Objective:To investigate the effects of low molecular weight heparin on kallikrein level in patients with preeclampsia. Methods:Ninety-six patients with preeclampsia were divided into the observation group and control group by random number table method(48 cases each group). The control group were treated with conventional therapy,the observation group were additionally treated with 0. 3 to 0. 4 mL of low molecular weight heparin by subcutaneous injection based on the conventional therapy,once a day,up to before 12 to 24 h of delivery. The blood pressure,24 h urine volume,urine protein quantity,blood platelet,coagulation function,maternal and neonatal outcomes and pregnancy outcome and kallikrein expression between the two groups were compared. Results:After the treatment,the systolic pressure,diastolic pressure and urine protein quantity in observation group were obviously lower than those in control group(P0. 05). The D-dimer level in observation group was obviously lower than that in control group after treatment(P0.05),观察组患者D-二聚体水平显著低于对照组(P<0.01).观察组患者新生儿胎龄、体质量及延长妊娠时间均显著高于对照组(P<0.01).治疗后观察组患者血液、胎盘和尿中激肽释放酶基因表达水平均显著高于对照组(P<0.01).结论:低分子肝素能够有效促进子痫前期患者激肽释放酶基因表达水平升高,改善母婴结局.
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