目的:研究Merlin蛋白在非小细胞肺癌中的表达及临床意义.方法:免疫组织化学法测定45例非小细胞肺癌组织、癌旁组织、正常组织的Merlin蛋白的表达,并对癌组织中的表达与其组织学分型、性别、P-TNM分期、分化程度及淋巴结转移情况等因素进行分析.结果:Merlin蛋白在正常组织及肺癌组织中阳性率分别为15.56%和73.33%,2组表达差异有统计学意义(P＜0.05);Merlin蛋白在肺癌组织中的表达与患者组织学分型、性别、P-TNM分期、分化程度及淋巴结转移情况均无关(P＞0.05).结论:Merlin蛋白可能与非小细胞肺癌的发生相关.%Objective To determine the expression and clinical significance of Merlin protein in non-small cell lung cancer (NSCLC).Methods The expression of Merlin protein in 45 cases of NSCLC and adjacent tissue of NSCLC and normal lung tissue was checked by immunohistochemistry.The relation between the expression of Merlin protein and the multiple factors of pathological type, gender, P-TNM stage, differentiation and lymph node metastasis was analyzed.Results The expression rates of Merlin protein in NSCLC and normal lung tissue sections were 73.33％ and 15.56％, respectively ( P ＜ 0.05 ).The expression of Merlin protein was not associated with the pathological type, gender, P-TNM stage, differentiation and lymph node metastasis ( P ＞ 0.05 ).Conclusion Merlin protein might contribute to the initiation of metastasis of NSCLC.
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