Objective:To study the value of procalcitonin (PCT) and C-reactive protein (CRP) for early diagnosis of late-onset neonatal community-acquired sepsis. Methods:48 cases diagnosed (blood culture positive) late-onset neonatal community-acquired sepsis from 2012.1 to 2013.2 were taken as observation group, while 36 cases non infectious newborns at the same time were taken as control group. The PCT and CRP level in serum of newborns in 2 groups were detected. Results: The PCT and CRP level in serum of newborns in observation group were all obviously higher than that in control group (P< 0.01). Although the sensitivity, specificity, positive predictive value, negative predictive value, accuracy and Youden index of PCT were slightly higher than CPR, but there had no statistical significance between them (P> 0.05). The specificity was 95.1%, sensitivity was 58.9% when joint detecting PCT and CRP. Conclusions:PCT and CRP can be act as index for early diagnosis of late-onset neonatal community-acquired sepsis, joint detection of them can improve specificity andreducemisdiagnosis rate.%目的：探讨降钙素原(PCT)、C反应蛋白(CRP)对新生儿社区获得性败血症晚发型的早期诊断价值。方法：以2012年1月至2013年12月收治的48例新生儿社区获得性败血症晚发型确诊病例(血培养阳性)为观察组，选取同期住院的非感染新生儿36例作为对照组，检测两组新生儿PCT和CRP的水平。结果：观察组患儿血清PCT和CRP水平均明显高于对照组，差异具有统计学意义(P ＜0.01)；PCT的灵敏度、特异度、阳性预测值、阴性预测值、正确率、约登指数均略高于CRP，但差异无统计学意义(P ＞0.05)。PCT和CRP联合检测的特异度为95.1%，敏感度为58.9%。结论：PCT、CRP可作为新生儿社区获得性败血症晚发型早期诊断的指标，二者联合检测可提高特异度、降低误诊率。
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