肿瘤血管生成是神经胶质瘤的重要病理生理特征,针对肿瘤血管生成的治疗是目前研究的热点.本文综述国内外对于神经胶质瘤血管生成的研究,包括神经胶质瘤血管生成的动物模型、细胞机制、调节因子、信号通路、抗血管生成药物和蛋白质组学等方面,明确目前的研究和临床治疗方面的现状,为进一步深入研究神经胶质瘤血管生成的分子机制、发现肿瘤血管生成新的标志物和治疗靶点提供参考,以期为神经胶质瘤提供新的诊断和治疗策略.%Tumor angiogenesis is the important pathophysiological characteristics of human glioma.The treatment of tumor angiogenesis is currently a hot research topic.This article reviewed the domestic and international research on angiogenesis of glioma,included animal models,cellular mechanisms,regulatory factors,signaling pathways,antiangiogenic drugs,and proteomics regarding glioma angiogenesis to clarify the current status of research and clinical treatment,providing reference for further study on angiogenesis of glioma,and discovery of novel biomarkers of tumor angiogenesis and therapeutic targets.
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