目的：探讨血清 IgE 与免疫球蛋白游离轻链在变应性鼻炎中的表达及意义。方法分析2013年1月至2014年12月接受治疗的变应性鼻炎患者的临床资料，设为观察组。同时选取同时期行体检的健康人群作为对照组。观察比较两组对象血清中白介素（IL）-4、IL -9、IL -17、IgE、免疫球蛋白游离轻链、κFLC、λFLC 水平。分析观察组患者IgE 与 IL -4、IL -9、IL -17的相关性和 IgE 与λFLC、κFLC 水平的相关性。结果观察组患者血清中 IL -4、IL -9、IL -17与 IgE 水平显著高于对照组，差异具有统计学意义（ P ﹤0.05）；采用 Pearson 相关性检验分析观察组患者血清中 IgE与 IL -4、IL -17水平的相关性，观察组患者 IgE 与 IL -4（ r =0.576，P ﹤0.001）及 IL -17（ r =0.584，P ﹤0.001）呈现显著正相关；观察组患者血清中κFLC、λFLC 水平显著高于对照组，差异具有统计学意义（ P ﹤0.05）；观察组患者血清IgE 与λFLC（ r =0.653，P ﹤0.001）、κFLC（ r =0.625，P ﹤0.001）水平呈现显著正相关。结论变应性鼻炎患者 IgE与 IL -4及 IL -17呈现显著正相关，血清中 IgE 与免疫球蛋白游离轻链水平亦呈现正相关关系，血清中 IgE 和免疫球蛋白游离轻链含量水平对变应性鼻炎的诊断具有一定的临床价值。significant positive correlation with IgE in patients with allergic rhinitis，serum level of IgE also has positive correlation with levels of free light chain immunoglobulin，serum levels of IgE and free light chain immunoglobulin have certain clinical significance in the diagnosis of allergic rhinitis.%Objective To explore the expression and significance of serum IgE and immunoglobulin free light chain in allergic rhinitis. Methods The clinical data of patients with allergic rhinitis for treatment in this hospital during January 2013 to December 2014 were selected as observation group. At the same time,healthy persons in the hospital were selected as control group. Results Serum levels of IL - 4,IL - 9 IL -17 and IgE in patients of observation group were significantly higher than those of control group,and the difference was statistically significant( P﹤ 0. 05). Pearson correlation test method had been applied to analyze the correlation of serum levels of IgE,IL - 4 and IL - 17 in patients of ob-servation group,levels of IL - 4( r = 0. 576,P ﹤ 0. 001)and IL - 17( r = 0. 584,P ﹤ 0. 001)in patients of observation group showed signifi-cant positive correlation with serum level of IgE;serum levels of κFLC and λFLC in patients of observation group were significantly higher than those of control group,and the difference was statistically significant( P ﹤ 0. 05). Serum levels of IgE,λFLC( r = 0. 653,P ﹤ 0. 001)andκFLC( r = 0. 625,P ﹤ 0. 001)in patients of observation group showed significant positive correlation. Conclusion IL - 4 and IL - 17 have significant positive correlation with IgE in patients with allergic rhinitis,serum level of IgE also has positive correlation with levels of free light chain immunoglobulin,serum levels of IgE and free light chain immunoglobulin have certain clinical significance in the diagnosis of allergic rhinitis.
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