Acute-on-chronic liver failure (ACLF) is a critical disease in clinical practice and has a mortality rate as high as 80％.At present,there are still no ideal therapeutic measures for ACLF.Stem cell transplantation has unique advantages in the treatment of ACLF;however,there are still some issues regarding the research on stem cell transplantation,which limit its clinical application.This article elaborates on conventional treatment methods,source of stem cells,transplantation approach,and related issues,in order to provide help for further studies.%慢加急性肝衰竭(ACLF)是临床上的危重疾病,病死率高达80％.目前临床对于ACLF仍缺乏理想的治疗措施.干细胞移植技术治疗ACLF具有其独特的优势,但现阶段关于该技术治疗ACLF的研究仍存在一些问题,因此导致其临床应用受到了限制.从传统治疗手段、干细胞来源、移植途径以及所存在的问题等4个方面对干细胞移植治疗ACLF进行阐述,以期对未来相关研究有所帮助.
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