非酒精性脂肪性肝病(NAFLD)是除外酒精和其他明确的肝损害因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征.“二次打击”学说可以部分解释NAFLD的发病机制.神经酰胺是NAFLD发生发展中关键的分子信使,而且其作为一种鞘脂与“二次打击学说”密切相关.对神经酰胺在NAFLD中的作用进行了综述.%Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome caused by liver damage factors except alcohol and has the major feature of diffuse macrovesicular hepatocyte steatosis.The " two-hit" hypothesis can partly explain the pathogenesis of NAFLD.Recent studies have found that ceramide is a key molecular messenger involved in the development and progression of NAFLD,and as a sphingolipid,it is closely associated with the "two-hit" hypothesis.This article reviews the role of ceramide in NAFLD.
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