Obesity has become a severe public health issue.Studies have shown that obesity is closely associated with metabolic disease and the development and progression of various tumors.This article summarizes the obesity-related factors in the development and progression of liver cancer,including adipokines (such as leptin,insulin like growth factor-1,interleukin-6,tumor necrosis factor-α,and adiponectin),insulin,insulin resistance,oxidative stress response,intestinal microecological disorders,and regulations of PNPLA3,miRNA,TM6SF2,and JAZF1 genes.This article reviews the research advances in these mechanisms,in order to provide guidance for the prevention and treatment of liver cancer.%肥胖除了与代谢相关性疾病有关外,还与多种肿瘤的发生发展有着紧密关系.归纳了肥胖对肝癌发生发展影响的几种作用机制,包括:瘦素、胰岛素样生长因子1、IL-6、TNFα、脂联素等脂肪细胞因子,胰岛素,胰岛素抵抗,氧化应激反应,肠道微生态紊乱,以及含patatin样磷脂酶域3、miRNA、TM6SF2、和JAZF1等基因方面的调节,对其作用机制的研究进展加以综述,以期对肝癌的预防和治疗起到积极的指导作用.
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