Hepatitic C virus (HCV) infection is the main cause of chronic liver disease. Most of the infected individuals develop persistent infection which is closely related to liver cirrhosis and hepatocellular carcinoma. In the last decade, many researchers spared no efforts to establish varieties of mouse models, which enrich and deepen the view of molecular mechanisms of HCV infection, pathogenicity and immunity. The new anti-viral strategies and specific drug screening were simultaneously developed. In this paper, two types of most common experimental mouse models are reviewed.%丙型肝炎病毒(HCV)感染是导致慢性肝病的主要原因.大部分HCV感染者呈持续性感染,这与肝硬化和肝细胞癌紧密相关.近十年来,许多学者通过不懈的努力建立了各种行之有效的小鼠实验模型,基于这些模型的研究极大地丰富和加深了对HCV感染、致病、免疫等方面分子机理的认识,同时也极大地促进了新的抗病毒策略和特异药物筛选的发展.本文就目前最常见和未来有应用前景的两类小鼠实验模型作一综述.
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